| Autor: |
Doucet J; Service de Médecine Interne-Diabétologie, CHU de Rouen, Hôpital de Boisguillaume., Senant J, Ménard JF, Fresel J, Schrub JC |
| Jazyk: |
francouzština |
| Zdroj: |
Therapie [Therapie] 1991 Jul-Aug; Vol. 46 (4), pp. 315-8. |
| Abstrakt: |
This study was a 6-month open trial of the effects of naftidrofuryl fumarate (600 mg/day orally) on the clinical and electrophysiological signs of diabetic polyneuropathy in 15 patients. A scored clinical evaluation and an indexed electrophysiological examination were done at inclusion, and after 3 and 6 months. Mean clinical score and electrophysiological index was improved after 3 months of therapy, the improvement persisting at 6 months, with no change in control of diabetes. These results could be related to the vasodilating properties of the drug, causing an increase in nerve temperature, or to a specific neurotropic action, as recently demonstrated in rats. Controlled studies are necessary to confirm these results, and explore the mechanism of this improvement. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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