| Autor: |
Karapetyan YE; Department of Infectology, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America., Saá P, Mahal SP, Sferrazza GF, Sherman A, Salès N, Weissmann C, Lasmézas CI |
| Jazyk: |
angličtina |
| Zdroj: |
PloS one [PLoS One] 2009 May 29; Vol. 4 (5), pp. e5730. Date of Electronic Publication: 2009 May 29. |
| DOI: |
10.1371/journal.pone.0005730 |
| Abstrakt: |
Prion strain identification has been hitherto achieved using time-consuming incubation time determinations in one or more mouse lines and elaborate neuropathological assessment. In the present work, we make a detailed study of the properties of PrP-overproducing Tga20 mice. We show that in these mice the four prion strains examined are rapidly and faithfully amplified and can subsequently be discriminated by a cell-based procedure, the Cell Panel Assay. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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