| Autor: |
Vorkunova GK, Kalnina LB, Burshteĭn ME, Serbin AV, Rodionov IL, Pavlova MV, Bukrinskaia AG |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy virusologii [Vopr Virusol] 2009 Mar-Apr; Vol. 54 (2), pp. 27-31. |
| Abstrakt: |
Two groups of the antiviral agents: 1) adamantane- and norbornen-containing compounds with in-built cholesterol to potentiate the membranotropic properties and 2) synthetic matrix protein peptides (peptides A and B) were found to have effects on HIV replication. The agents of the former group produced antiviral activity only when added in combination with the virus. Peptide A (matrix protein 43-60 amino acids) inhibited viral replication when added in both the early and late periods. Fluorescein-labeled peptide A was detectable in the cytoplasm and nucleus (although adsorption of a portion of the peptides cannot be excluded onto the cell surface). Peptide A was shown to inhibit Gag precursor p55 transport from the nuclei to the plasma membrane, the site of virus assembly. Peptide B had no antiviral activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
