The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical study.

Autor:	Genç E; Department of Neurology, Meram School of Medicine, Selcuk University, Konya, Turkey. eminegencduran@gmail.com, Avunduk MC, Genç BO, Sahin AS, Oz M
Jazyk:	angličtina
Zdroj:	Acta neurologica Scandinavica [Acta Neurol Scand] 2009 Oct; Vol. 120 (4), pp. 264-9. Date of Electronic Publication: 2009 Apr 20.
DOI:	10.1111/j.1600-0404.2008.01153.x
Abstrakt:	Objective: To investigate the effects of chronic high dose sumatriptan and dipyrone treatment on central serotonergic system in rats. Materials and Methods: Male Sprague-Dawley rats (seven per group) were daily injected with sumatriptan (3 mg/kg), dipyrone (400 mg/kg) or saline for 30 days. The brains of animals were surgically removed and immunohistochemically stained for serotonin. Serotonin-positive stained cells were counted automatically by using a computerized image analysis program. Statistical analysis carried out using one-way ANOVA followed by post hoc Tukey test. Results: A significant decrease in serotonin-positive cells in the brainstem was observed after chronic sumatriptan administration while chronic use of dipyrone induced a significant increase in serotonin-positive cells both in the cortex and midbrain. Conclusion: Our data suggest that central serotonergic system might be modified by chronic use of sumatriptan and dipyrone. ((c) 2009 The Authors Journal compilation (c) 2009 Blackwell Munksgaard.)
Databáze:	MEDLINE
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