| Autor: |
Perel'muter VM, Zav'ialova MV, Vtorushin SV, Slonimskaia EM, Kritskaia NG, Garbukov EIu, Litviakov NV, Stakheeva MN, Babyshkina NN, Malinovskaia EA, Denisov EV, Grigor'eva ES, Nazarenko MS, Sennikov SV, Goreva EP, Kozlov VA, Voevoda MI, Maksimov VN, Beliavskaia VA, Cherdyntseva NV |
| Jazyk: |
ruština |
| Zdroj: |
Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2008; Vol. 21 (4), pp. 643-53. |
| Abstrakt: |
This study involved 525 breast cancer (BC) patients of T2-4N0-2M0 stages at the age of 35 years and older. Significant differences in clinical and pathological characteristics between premenopausal and postmenopausal BC patients were found. Mostly marked differences were shown for positive lymph node correlation with distant metastasis, multicentric growth and local recurrence depending on menopause status. The prevalence of various morphological structures in primary tumors was appeared to be associated with different forms of tumor progression in pre- and postmenopausal women. We have studied polymorphisms in 15 genes involved in major cancer related pathways (apoptosis, interleukins, folate metabolism enzymes genes). We found that variant genotypes of MTHFR and DHFR genes were associated with an increased BC risk among premenopausal women while polymorphism in IL-18, p53 genes were associated with BC among postmenopausal women. These results demonstrate novel biological information, which points the different mechanisms contributed to breast cancer progression in premenopausal and postmenopausal women. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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