Role of diffusion- and perfusion-weighted MR imaging for brain tumour characterisation.

Autor: Rizzo L; Istituto di Radiologia Università di Torino Sede San Luigi, Orbassano, Italy. lrizzo@sirm.org, Crasto SG, Moruno PG, Cassoni P, Rudà R, Boccaletti R, Brosio M, De Lucchi R, Fava C
Jazyk: English; Italian
Zdroj: La Radiologia medica [Radiol Med] 2009 Jun; Vol. 114 (4), pp. 645-59. Date of Electronic Publication: 2009 May 06.
DOI: 10.1007/s11547-009-0401-y
Abstrakt: Purpose: This study was undertaken to correlate apparent diffusion coefficient (ADC) and relative regional cerebral blood volume (rrCBV) to histological findings in a large series of patients with primary or secondary brain tumours to evaluate diffusion-weighted (DWI) and perfusion-weighted (PWI) imaging in the characterisation of cerebral tumors.
Materials and Methods: Ninety-eight patients with cerebral tumours, 46 of which were primary (seven grade 0-I, nine low-grade gliomas, two gliomatosis cerebri, nine lymphomas and 19 high-grade gliomas) and 52 secondary, underwent conventional magnetic resonance (MR) imaging completed with DWI and dynamic contrast susceptibility PWI. Both ADC and rrCBV were calculated on a workstation by using Functool 2 software. Student's t test was used to determine any statistically significant differences in the ADC and rrCBV values.
Results: Seventeen of 98 tumours were cystic or necrotic (12/17 hypointense and 5/17 hyperintense on DWI); the ADC value of hyperintense cystic areas was 0.97+/-0.23x10(-3) mm2/s. The ADC value of solid tumours varied between 0.64 and 3.5x10(-3) mm2/s. The rrCBV value was 1.4 (sigma 0.66) in low-grade gliomas; 1.22 (sigma 0.25) in lymphomas; 4.5 (sigma 0.85) in grade III gliomas; 3.18 (sigma 1.26) in grade IV gliomas and 2.53 (sigma 1.6) in metastases.
Conclusions: DWI has an important role in the differential diagnosis of cystic cerebral masses but not in tumour characterisation. PWI is helpful in differentiating high-from low-grade gliomas and lymphomas from high-grade gliomas.
Databáze: MEDLINE
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