Inhibitory effects of Solidago chilensis Meyen hydroalcoholic extract on acute inflammation.

Autor: Tamura EK; Area de Ciências da Saúde, Universidade Braz Cubas, Mogi das Cruzes, SP, Brazil., Jimenez RS, Waismam K, Gobbo-Neto L, Lopes NP, Malpezzi-Marinho EA, Marinho EA, Farsky SH
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2009 Apr 21; Vol. 122 (3), pp. 478-85. Date of Electronic Publication: 2009 Jan 31.
DOI: 10.1016/j.jep.2009.01.029
Abstrakt: Aim of the Study: Alcoholic or hydroalcoholic preparations of the plant Solidago chilensis Meyen (Asteraceae) are employed in popular medicines to treat inflammation. The anti-inflammatory effects of the hydroalcoholic extract of aerial parts of the plant (93% ethanol) were investigated and the main components of the extract were identified.
Materials and Methods: Ear oedema was induced in male Wistar rats by topical application of the chloroform fraction of latex-extract from Euphorbia milii. Leukocyte mobilisation was quantified after air-pouch inflammation evoked by oyster glycogen. Leukocyte-endothelial interactions and mast cell degranulation were quantified by intravital microscopy. The extract itself was characterised via HPLC-DAD-MS and HPLC-MS/MS.
Results: Topical (12.5-50mg/kg) or intraperitoneal (25 or 50mg/kg) administrations of the extract reduced ear oedema formation (>25% reduction). Intraperitoneal applications of 25mg/kg of extract inhibited the migration of polymorphonuclear cells into the inflamed cavity (about 50%). In addition, the rolling behaviour and adherence of circulating leukocytes to postcapillary venules of the mesentery network was diminished (50%), but the mast cell degranulation in the perivascular area was not affected. The major components of the extract were identified as caffeoylquinic acid derivatives and the flavonoid rutin.
Conclusions: The data presented herein show local and systemic anti-inflammatory effects of the hydroalcoholic extract of aerial parts of Solidago chilensis, and implicate the inhibition of leukocyte-endothelial interactions as an important mechanism of the extract's action.
Databáze: MEDLINE
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