Using tree diversity to compare phylogenetic heuristics.
| Autor: | Sul SJ; Department of Computer Science and Engineering, Texas A&M University, College Station, Texas, USA. sulsj@cs.tamu.edu, Matthews S, Williams TL |
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| Jazyk: | angličtina |
| Zdroj: | BMC bioinformatics [BMC Bioinformatics] 2009 Apr 29; Vol. 10 Suppl 4, pp. S3. Date of Electronic Publication: 2009 Apr 29. |
| DOI: | 10.1186/1471-2105-10-S4-S3 |
| Abstrakt: | Background: Evolutionary trees are family trees that represent the relationships between a group of organisms. Phylogenetic heuristics are used to search stochastically for the best-scoring trees in tree space. Given that better tree scores are believed to be better approximations of the true phylogeny, traditional evaluation techniques have used tree scores to determine the heuristics that find the best scores in the fastest time. We develop new techniques to evaluate phylogenetic heuristics based on both tree scores and topologies to compare Pauprat and Rec-I-DCM3, two popular Maximum Parsimony search algorithms. Results: Our results show that although Pauprat and Rec-I-DCM3 find the trees with the same best scores, topologically these trees are quite different. Furthermore, the Rec-I-DCM3 trees cluster distinctly from the Pauprat trees. In addition to our heatmap visualizations of using parsimony scores and the Robinson-Foulds distance to compare best-scoring trees found by the two heuristics, we also develop entropy-based methods to show the diversity of the trees found. Overall, Pauprat identifies more diverse trees than Rec-I-DCM3. Conclusion: Overall, our work shows that there is value to comparing heuristics beyond the parsimony scores that they find. Pauprat is a slower heuristic than Rec-I-DCM3. However, our work shows that there is tremendous value in using Pauprat to reconstruct trees-especially since it finds identical scoring but topologically distinct trees. Hence, instead of discounting Pauprat, effort should go in improving its implementation. Ultimately, improved performance measures lead to better phylogenetic heuristics and will result in better approximations of the true evolutionary history of the organisms of interest. |
| Databáze: | MEDLINE |
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