| Autor: |
Gøgsig TM; The Center for Insoluble Protein Structures (inSPIN), Department of Chemistry and the Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus, Denmark., Lindhardt AT, Dekhane M, Grouleff J, Skrydstrup T |
| Jazyk: |
angličtina |
| Zdroj: |
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2009 Jun 08; Vol. 15 (24), pp. 5950-5. |
| DOI: |
10.1002/chem.200900313 |
| Abstrakt: |
Heteroaromatic 2-pyridyl tosylates were successfully applied as electrophiles in palladium(0)-catalyzed Mizoroki-Heck-coupling reactions to electron-rich olefins with complete alpha-regioselectivity. This protocol represents a general strategy for the application of pyridyl tosylates and mesylates in the Mizoroki-Heck coupling. The catalytic system also proved adaptable to changes in the heteroaromatic core as well as large-scale applications. Finally, the synthetic utility of the functionalized alpha-heteroarylvinyl amides was established providing straightforward access to highly functionalized heteroaromatic compounds including chiral benzylic amide derivatives. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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