Dermoscopic patterns and subclinical melanocytic nests in normal-appearing skin.

Autor: Scope A; Memorial Sloan-Kettering Cancer Center, New York, NY 10022, USA., Marghoob AA, Chen CS, Lieb JA, Weinstock MA, Halpern AC
Jazyk: angličtina
Zdroj: The British journal of dermatology [Br J Dermatol] 2009 Jun; Vol. 160 (6), pp. 1318-21. Date of Electronic Publication: 2009 Mar 11.
DOI: 10.1111/j.1365-2133.2009.09073.x
Abstrakt: Background: Dermoscopic patterns of normal-appearing skin have received little scrutiny. We have recently completed an analysis of dermoscopic patterns of naevi in children.
Objectives: To describe dermoscopic patterns in the normal-appearing skin surrounding naevi and to explore histological features of patterned background skin.
Methods: Dermoscopic images of back naevi were obtained from a population-based sample of fifth grade students. The dermoscopic pattern of the background skin around the naevi was analysed. We examined histopathological features of background skin patterns in a convenience sample of seven specimens from six adult patients.
Results: We observed a dermoscopic pattern in the background of normal-appearing skin in 41% of 1192 dermoscopic images from the backs of the 443 children. The background skin pattern was less frequent in individuals with a fair skin (P < 0.001). A globular pattern was observed in 201 images (17%) and a reticular pattern was seen in 287 images (24%), of which 112 images also showed globules. Inter-rater reliability between the two observers for a random sample of 100 images was excellent (kappa = 0.77). In four specimens with a globular background pattern, microscopic melanocytic nests were observed in the normal-appearing skin. No subclinical naevus nests were observed in three reticular pattern specimens.
Conclusions: Dermoscopically recognized patterns are commonly present in clinically normal skin of children. Microscopic melanocytic nests may be observed in normal-appearing skin with a globular skin pattern.
Databáze: MEDLINE
Externí odkaz: