| Autor: |
Valdivia-Silva JE; Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, C.P. 04510 DF, Mexico., Franco-Barraza J, Silva AL, Pont GD, Soldevila G, Meza I, García-Zepeda EA |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer letters [Cancer Lett] 2009 Oct 08; Vol. 283 (2), pp. 176-85. Date of Electronic Publication: 2009 May 05. |
| DOI: |
10.1016/j.canlet.2009.03.040 |
| Abstrakt: |
Interactions between tumour cells and microenvironments may affect their growth and metastasis formation. In search for a better understanding of the role of cellular mediators in the progression of cancer, we investigated the effect of pro-inflammatory cytokines IL-1, IL-6, TNF-alpha and IFN-gamma on the regulation of expression of chemokine receptors CXCR4, CXCR2, CX3CR1, CCR9, and CCR5 in the human breast cancer cell line MCF-7. Our results showed that IL-1 increased CXCR4 expression whereas TNF-alpha increased CX3CR1, CCR9 and CCR5. Interestingly, this regulation was not homogeneous, emphasizing the inherent heterogeneity in cancer that may be responsive to specific inflammatory microenvironments. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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