The presentation and clinical course of intracranial developmental venous anomalies in adults: a systematic review and prospective, population-based study.
| Autor: | Hon JM; Division of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, UK., Bhattacharya JJ, Counsell CE, Papanastassiou V, Ritchie V, Roberts RC, Sellar RJ, Warlow CP, Al-Shahi Salman R |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Stroke [Stroke] 2009 Jun; Vol. 40 (6), pp. 1980-5. Date of Electronic Publication: 2009 Apr 23. |
| DOI: | 10.1161/STROKEAHA.108.533034 |
| Abstrakt: | Background and Purpose: Reported risks of hemorrhage from intracranial developmental venous anomalies (DVAs) vary, so we investigated this in a systematic review and population-based study. Methods: We systematically reviewed the literature (Ovid Medline and Embase to November 7, 2007) and selected studies of >or=20 participants with >or=1 DVA(s) that described their clinical presentation and/or their clinical course over a specified follow-up period. We also identified every adult first diagnosed with a DVA in Scotland from 1999 to 2003 and followed them in a prospective, population-based study. Results: Of 2068 articles detected by the literature search, 15 met our inclusion criteria and described clinical presentation, 8 of which also described the clinical course of DVAs. In the 15 studies of 714 people first presenting with a DVA, 61% were incidental findings, the mode of presentation was unclear in 23%, 6% presented with nonhemorrhagic focal neurological deficit, 6% had caused symptomatic hemorrhage, 4% were associated with epileptic seizure, and <1% were associated with infarction. In studies of the clinical course of 422 people with a DVA, the hemorrhage rate after first presentation ranged from 0% to 1.28% per year. In the population-based study of 93 adults with DVAs, 98% were incidental, 1% presented with symptomatic hemorrhage, and 1% presented with an infarct, but there were no symptomatic hemorrhages or infarcts in 492 person-years of follow-up (0% per person-year; 95% CI, 0% to 0.7%). Conclusions: Intracranial DVAs have a benign presentation and clinical course. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|