| Autor: |
Storms WW, Bierman CW, Chai H, Dockhorn RJ, Eggleston P, Ellis EF, Feldman C, Fink JN, Hemstreet MP, Kniker WT, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of asthma : official journal of the Association for the Care of Asthma [J Asthma] 1991; Vol. 28 (5), pp. 369-79. |
| DOI: |
10.3109/02770909109089464 |
| Abstrakt: |
This multiclinic study was performed to evaluate the safety and efficacy of metaproterenol sulfate (Alupent) metered dose inhaler in children with asthma ages 5 to 12 years. A total of 268 children completed this study according to the protocol, having received either metaproterenol or placebo for 30 consecutive days. Full spirometric testing was done pre- and postdose on Days 1 and 30 for a total duration of 6 hours on each day. The results showed that metaproterenol was consistently superior to placebo in all pulmonary function parameters measured on Days 1 and 30. This difference was statistically significant for peak values and areas under the curves for both FEV1 and FEF25-75%. There were no significant side effects noted. We conclude that metaproterenol metered dose inhaler is safe and effective in the treatment of asthma in children ages 5 to 12 years. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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