| Autor: |
Buchner KM; Department of Chemistry, University of California, Irvine, California 92697-2025, USA., Clark TB, Loy JM, Nguyen TX, Woerpel KA |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2009 May 21; Vol. 11 (10), pp. 2173-5. |
| DOI: |
10.1021/ol900456v |
| Abstrakt: |
Several alkylidenesilacyclopropanes were prepared by silver-mediated silylene transfer to allenes. Oxasilacyclopentanes derived from allenes were prepared with high regio- and diastereoselectivity by a two-step, one-flask silacyclopropanation/carbonyl insertion reaction. Triols and homoallylic alcohols were formed diastereoselectively by functionalizing the oxasilacyclopentanes. An optically active allene (>98% ee) was utilized to synthesize an enantiopure homoallylic alcohol in 96% ee. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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