| Autor: |
Heringer-Walther S; 1Department of Gynaecology, University of Leipzig, Germany., Eckert K, Schumacher SM, Uharek L, Wulf-Goldenberg A, Gembardt F, Fichtner I, Schultheiss HP, Rodgers K, Walther T |
| Jazyk: |
angličtina |
| Zdroj: |
Haematologica [Haematologica] 2009 Jun; Vol. 94 (6), pp. 857-60. Date of Electronic Publication: 2009 Apr 18. |
| DOI: |
10.3324/haematol.2008.000034 |
| Abstrakt: |
Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34(+) and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1-7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I(+) and CD34(+) cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1-7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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