| Autor: |
Sanders MT; Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia., Deliyannis G, Pearse MJ, McNamara MK, Brown LE |
| Jazyk: |
angličtina |
| Zdroj: |
Vaccine [Vaccine] 2009 Apr 21; Vol. 27 (18), pp. 2475-82. Date of Electronic Publication: 2009 Feb 24. |
| DOI: |
10.1016/j.vaccine.2009.02.054 |
| Abstrakt: |
The effectiveness of single dose, intranasally delivered vaccines comprising detergent-disrupted inactivated influenza virus (split virus) and ISCOMATRIX adjuvant was examined in mice. Vaccines formulated with adjuvant required 10- to 100-fold less split virus antigen to induce pulmonary protection following viral challenge when compared to vaccines containing split virus alone. Furthermore, those formulated with ISCOMATRIX adjuvant elicited specific antibody in serum, saliva, vaginal, nasal and lung fluids when delivered to the entire respiratory tract. No specific antibody was detected in serum or mucosal samples, however, when the same vaccines were delivered using a procedure that restricted the inoculum to the nasal passages. Good protective responses can thus be achieved with only a single intranasal inoculation of influenza vaccine formulated with adjuvant, providing the vaccine can access sites of immune induction in the lower respiratory tract. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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Full Text from ScienceDirect