| Abstrakt: |
The role of C virus structural and non-structural proteins and cytokines in pathogenesis of chronic hepatitis is considered. The levels of antibodies to cor-protein and non-structural NS5 protein are found to correlate with viral load. An elevated level of NS5 of tumour necrosis factor, interleukin-8 , and IL-10 is a predictor of unfavourable prognosis of interferon therapy whereas enhanced synthesis of IL-2 and IL-4 suggests good outcome of such treatment. Antibodies against IL-8, IL-10, IL-22, and TNF are currently used to develop new antiviral preparations. |
