| Autor: |
Martino S; Department of Experimental Medicine and Biochemical Science, Section of Biochemistry and Molecular Biology, University of Perugia, Perugia, Italy., D'Angelo F, Armentano I, Tiribuzi R, Pennacchi M, Dottori M, Mattioli S, Caraffa A, Cerulli GG, Kenny JM, Orlacchio A |
| Jazyk: |
angličtina |
| Zdroj: |
Tissue engineering. Part A [Tissue Eng Part A] 2009 Oct; Vol. 15 (10), pp. 3139-49. |
| DOI: |
10.1089/ten.TEA.2008.0552 |
| Abstrakt: |
The interaction between stem cells and biomaterials with nanoscale topography represents a main route in the roadmap for tissue engineering-based strategies. In this study, we explored the interface between human bone marrow-derived mesenchymal stem cells (hBM-MSCs) and hydrogenated amorphous carbon (a-C:H) film designed with uniform, groove, or grid nanopatterns. In either case, hBM-MSCs preserved growth rate and multi-differentiation properties, suggesting that the films were biocompatible and suitable for stem cell culture. hBM-MSCs responded to different nanopattern designs with specific changes of microtubule organization. In particular, the grid pattern induced a square-localized distribution of alpha-tubulin/actin fibers, whereas the groove pattern exerted a more dynamic effect, associated with microtubule alignment and elongation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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