| Autor: |
Price KE; Chemical Research and Development, Pfizer, Inc., Eastern Point Road, Groton, Connecticut 06340, USA., Larrivée-Aboussafy C, Lillie BM, McLaughlin RW, Mustakis J, Hettenbach KW, Hawkins JM, Vaidyanathan R |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2009 May 07; Vol. 11 (9), pp. 2003-6. |
| DOI: |
10.1021/ol900435t |
| Abstrakt: |
A mild, high-yielding, and practical protocol for the direct amidation of alkyl cyanoacetates using DBU is presented. This method eliminates the need for activation of cyanoacetic acid and/or high temperatures. It has been applied to the large-scale synthesis of CP-690,550-10 (1), a compound under development for the treatment of autoimmune diseases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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