[Practical value of the TB-biochip MDR test system in the rapid identification of multidrug-resistant M. tuberculosis strains].
| Substance Nomenclature: | 0 (Antibiotics, Antitubercular) 0 (Bacterial Proteins) 0 (rpoB protein, Mycobacterium tuberculosis) EC 1.11.1.6 (Catalase) EC 1.11.1.6 (katG protein, Mycobacterium tuberculosis) EC 2.7.7.6 (DNA-Directed RNA Polymerases) V83O1VOZ8L (Isoniazid) VJT6J7R4TR (Rifampin) |
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| Entry Date(s): | Date Created: 20090402 Date Completed: 20090428 Latest Revision: 20190816 |
| Update Code: | 20221213 |
| PMID: | 19334480 |
| Autor: | Isakova ZhT |
| Jazyk: | ruština |
| Zdroj: | Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2009 Feb (2), pp. 50-1. |
| Abstrakt: | For diagnostic assessment of the TB-biochip MDR test system, 455 sputum samples from new cases of pulmonary tuberculosis were tested. Unlike bacterial culture, the TB-biochip MDR test system allows identification of multidrug-resistant Mycobacterium tuberculosis (MBT) strains from mutations in the rpoB, katG, inhA, and ahpC genes rapidly during two days. Multidrug resistance of MBT to rifampicin and isoniazid was mainly due to the combined mutation Ser531 --> Leu in the rpoB gene and to the mutation Ser315 --> Thr in the katG gene. |
| Databáze: | MEDLINE |
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