The impact of aspirin resistance on the long-term cardiovascular mortality in patients with non-ST segment elevation acute coronary syndromes.

Autor: Foussas SG; Department of Cardiology, Tzanio Hospital, Piraeus, Greece., Zairis MN, Tsirimpis VG, Makrygiannis SS, Patsourakos NG, Adamopoulou EN, Mytas DZ, Prekates AA, Perdiou AJ, Tsoukanas VK, Argyrakis SK
Jazyk: angličtina
Zdroj: Clinical cardiology [Clin Cardiol] 2009 Mar; Vol. 32 (3), pp. 142-7.
DOI: 10.1002/clc.20293
Abstrakt: Background: Aspirin resistance has been associated with an adverse long-term outcome in patients with atherosclerotic coronary artery disease, but more studies are needed.
Hypothesis: The aim of this study was to investigate the impact of aspirin resistance, assessed by the Platelet Function Analyzer-100 (PFA-100) (Dade Behring Inc., Deerfield, Ill., USA) on the long-term prognosis in patients with non-ST segment elevation acute coronary syndromes (NSTE-ACS).
Methods: A total of 496 consecutive patients were studied. The 1-y incidence of cardiovascular death was the prespecified study endpoint. The patients were divided, according to the values of PFA-100 collagen epinephrine closure time (CEPI-CT) upon presentation, into aspirin sensitives (those with a PFA-100 CEPI-CT>193 sec) and aspirin resistants (those with a PFA-100 CEPI-CTResults: Aspirin resistants were younger (p-value = 0.04), and less frequently hypertensives (p-value=0.05) or diabetics (p-value=0.04) than aspirin sensitives. By 1 y, the incidence of cardiovascular deaths in the entire cohort was 12.9% (64/496), and aspirin resistants were at significantly higher risk of cardiovascular death (23.1% versus 9.6%; hazard ratio [HR]=2.6; 95% confidence interval [CI]=1.6-4.3; p-value<0.001), than aspirin sensitives. By multivariate Cox regression analysis, aspirin resistance (a PFA-100 CEPI-CTConclusion: According to the present data, aspirin resistance, assessed by the PFA-100, is an independent predictor of long-term cardiovascular mortality in patients with NSTE-ACS.
(Copyright (c) 2009 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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