Long-term histologic response to synthetic and biologic graft materials implanted in the vagina and abdomen of a rabbit model.

Autor: Pierce LM; Department of Obstetrics and Gynecology, Scott & White Memorial Hospital and Clinic, Texas A&M University Health Science Center College of Medicine, Temple, TX, USA., Rao A, Baumann SS, Glassberg JE, Kuehl TJ, Muir TW
Jazyk: angličtina
Zdroj: American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2009 May; Vol. 200 (5), pp. 546.e1-8. Date of Electronic Publication: 2009 Mar 16.
DOI: 10.1016/j.ajog.2008.12.040
Abstrakt: Objective: We sought to evaluate the effects of graft type, site of implantation, and ovariectomy on the long-term histologic response to graft materials used in pelvic reconstructive surgery.
Study Design: In all, 45 rabbits underwent ovariectomy or sham laparotomy and were implanted with polypropylene (PP) mesh (n = 23) or cross-linked porcine dermis (PS) (n = 22) in the vagina and abdomen. Grafts were harvested 9 months later and were processed for histology to evaluate the host inflammatory response and degree of tissue incorporation within the grafts.
Results: Polypropylene induced a milder (P < .007), more uniform response than PS, whereas PS elicited a more variable response and degraded by 9 months. Vaginal grafts had higher scores for inflammation (P = .005) and neovascularization (P < .001), and had lower scores for fibroblastic proliferation (P < .001) than abdominal grafts. Ovariectomy had no effect (P > .05).
Conclusion: Synthetic and biologic grafts evoke different foreign body responses, which may have implications for surgical outcomes in women.
Databáze: MEDLINE
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