| Autor: |
Mueller NJ; Department of Chemistry, Organic & Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, Austria., Stueckler C, Hall M, Macheroux P, Faber K |
| Jazyk: |
angličtina |
| Zdroj: |
Organic & biomolecular chemistry [Org Biomol Chem] 2009 Mar 21; Vol. 7 (6), pp. 1115-9. Date of Electronic Publication: 2009 Jan 26. |
| DOI: |
10.1039/b819057g |
| Abstrakt: |
Three FMN-dependent oxidoreductases, YcnD and YhdA from Bacillus subtilis and Lot6p from Saccharomyces cerevisiae, oxidised alpha,beta-unsaturated carbonyl compounds and a thioether, respectively, to furnish the corresponding racemic epoxides or sulfoxide, respectively. The mechanism of this enzyme-mediated (rather than enzyme-catalysed) oxidation was shown to proceed via the NADH-dependent reduction of O(2), forming H(2)O(2), which acted as oxidant in a spontaneous (non-enzymatic) fashion. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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