Altered flow-mediated vasodilatation, low paraoxonase-1 activity, and abnormal high-density lipoprotein subclass distribution in Takayasu's arteritis.
| Autor: | Espinola-Zavaleta N; Echocardiography in Out Patient Clinic, Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico., Soto-López ME, Carreón-Torres E, Gamboa R, Mejía AM, Márquez-Velasco R, Bojalil R, Huesca-Gomez C, Reyes PA, Pérez-Méndez O |
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| Jazyk: | angličtina |
| Zdroj: | Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2009 Apr; Vol. 73 (4), pp. 760-6. Date of Electronic Publication: 2009 Mar 05. |
| DOI: | 10.1253/circj.cj-08-0582 |
| Abstrakt: | Background: Takayasu's arteritis (TA) is an idiopathic chronic inflammatory disease that causes occlusion of large arteries, but little is known about whether affected patients are characterized by endothelial dysfunction, different high-density lipoproteins (HDL) subclasses and paraoxonase-1 (PON1) activity. Methods and Results: In the present study, 30 patients with TA, 30 age- and gender-matched volunteers (controls) and 15 patients with essential hypertension were studied. Flow-mediated vasodilation (FMD) and maximal blood flow velocity, assessed in the brachial artery by high-resolution ultrasound, were significantly lower in patients. HDL subclass distribution was determined by polyacrylamide gradient gel electrophoresis. HDL-cholesterol, HDL3b subclass and PON1 activity, assessed spectrophotometrically using phenylacetate as the substrate, were also lower in patients compared with controls. In a multiple regression analysis, the use of prednisone and systolic blood pressure were independent variables that predicted the FMD. Conclusions: A low FMD, abnormal size distribution of HDLs, and low PON1 activity are observed in TA patients. These abnormalities appear independently and constitute a cluster that may contribute to the vascular dysfunction of TA arteritis. |
| Databáze: | MEDLINE |
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