| Autor: |
Duque MD; Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Diagonal, 643, Barcelona E-08028, Spain., Camps P, Profire L, Montaner S, Vázquez S, Sureda FX, Mallol J, López-Querol M, Naesens L, De Clercq E, Prathalingam SR, Kelly JM |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2009 Apr 15; Vol. 17 (8), pp. 3198-206. Date of Electronic Publication: 2009 Feb 13. |
| DOI: |
10.1016/j.bmc.2009.02.007 |
| Abstrakt: |
The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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