[Binding of 2-acetylaminofluorene-9-14C with rat liver nucleic acids during malignization and in primary hepatomas].
| Autor: | Ivanov SD, Dzhioev FK |
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| Jazyk: | ruština |
| Zdroj: | Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1977 Mar; Vol. 83 (3), pp. 332-4. |
| Abstrakt: | The residual binding of 9-14C-2-Acetylaminofluorene (9-14C-2-AAF) with rat liver nuclei acids was investigated during hepatocarcinogenesis two weeks after a single injection of 9-14C-2-AAF. Up to 6 months feeding of the animals with unlabeled 2-AAF, the RNA of their liver proved to bind increased amounts of 9-14C-2-AAF in comparison with normal liver. The binding of 9-14C-2-AAF with DNA in primary hepatomas was mainly due to the RNA heterodispersed components with the maximum level in the 18S-fraction, as well as with the biopolymere fractions with the sedimentation constant of 10 and 5S enriched with polyadenylate fragments. |
| Databáze: | MEDLINE |
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