Cell adhesion molecule L1 affects the rate of differentiation of enteric neurons in the developing gut.

Autor: Turner KN; Department of Anatomy and Cell Biology, University of Melbourne, Australia., Schachner M, Anderson RB
Jazyk: angličtina
Zdroj: Developmental dynamics : an official publication of the American Association of Anatomists [Dev Dyn] 2009 Mar; Vol. 238 (3), pp. 708-15.
DOI: 10.1002/dvdy.21861
Abstrakt: The enteric nervous system arises predominantly from vagal level neural crest cells that migrate into and along the developing gut. As the neural crest-derived cells migrate within the gut, a subpopulation begins to differentiate into enteric neurons. Here, we show that the differentiation of neural crest-derived cells into enteric neurons is delayed in L1-deficient mice, compared with littermate controls. However, glial cell differentiation is not affected in L1-deficient mice. These mice also show a delay in the differentiation of a neurotransmitter-specific subtype of enteric neuron within the gastrointestinal tract. Together, these results suggest a role for the cell adhesion molecule, L1, in the differentiation of neural crest-derived cells into enteric neurons within the developing enteric nervous system.
((c) 2009 Wiley-Liss, Inc.)
Databáze: MEDLINE
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