Purification and viral inactivation of hemoglobin from human placenta blood.

Autor:	Li F; Tianjin University, China., Zhang H, Wang J, Yang C
Jazyk:	angličtina
Zdroj:	Artificial cells, blood substitutes, and immobilization biotechnology [Artif Cells Blood Substit Immobil Biotechnol] 2009; Vol. 37 (2), pp. 57-60. Date of Electronic Publication: 2009 Feb 18.
DOI:	10.1080/10731190902742547
Abstrakt:	A new procedure was developed to obtain high-quality polymerized human hemoglobin by modifying purified hemoglobin with PLP and polymerized with GDA. Comparing polymerized hemoglobin products obtained from different methods, the product from the new procedure has similar physical, chemical, and biological properties in the molecular distribution, methemoglobin concentration, oxygen carrier capacity, P(50) and spectral analysis. Furthermore, the new procedure of modification after polymerization can save PLP greatly, and significantly reduce the cost. So the procedure of modification after polymerization is a better way in research and production.
Databáze:	MEDLINE
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