| Autor: |
Stimac V; GSK Research Centre Zagreb Ltd, Zagreb, Croatia. vlado.z.stimac@gsk.com, Alihodzic S, Lazarevski G, Mutak S, Istuk ZM, Fajdetic A, Palej I, Paljetak HC, Marsic N, Padovan J, Tavcar B, Erakovic Haber V |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antibiotics [J Antibiot (Tokyo)] 2009 Mar; Vol. 62 (3), pp. 133-44. Date of Electronic Publication: 2009 Feb 13. |
| DOI: |
10.1038/ja.2009.1 |
| Abstrakt: |
A series of 4''-O-acyl derivatives of 8a-aza-8a-homoerythromycins A were synthesized and tested against Gram-positive and Gram-negative bacteria. Derivatives of 8a-aza-8a-homoerythromycin A have potent anti-bacterial activity against not only azithromycin-susceptible strains, but also efflux (M) and inducible macrolide-lincosamide-streptogramin-resistant Gram-positive pathogens. These compounds show moderate to high clearance and low oral bioavailability in preliminary in vivo pharmacokinetic studies in rat. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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