| Autor: |
Thayan R; Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia., Huat TL, See LL, Tan CP, Khairullah NS, Yusof R, Devi S |
| Jazyk: |
angličtina |
| Zdroj: |
Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2009 Apr; Vol. 103 (4), pp. 413-9. Date of Electronic Publication: 2009 Feb 08. |
| DOI: |
10.1016/j.trstmh.2008.12.018 |
| Abstrakt: |
Dengue infection is a major public health problem affecting millions of people living in tropical countries. With no suitable vaccines and specific antiviral drugs, treatment for dengue is usually symptomatic and supportive. Early diagnosis and recognition of severe disease is therefore crucial for better management of the patient. Two-dimension electrophoresis was used to identify disease-associated proteins that can be used for diagnosis and as drug targets for treatment. Two markers, identified by mass spectrometry analysis as alpha1-antitrypsin and NS1 proteins were found to be upregulated in dengue fever (DF; n=10) and dengue haemorrhagic fever (DHF; n=10) patients compared with healthy individuals (n=8). Both alpha1-antitrypsin and NS1 proteins were overexpressed two-fold in DHF patients compared with DF patients. Our study suggests that alpha1-antitrypsin and NS1 protein could be used as biomarkers as early indicators of DHF risk among patients with suspected dengue infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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