Delayed microbial cure of lymphogranuloma venereum proctitis with doxycycline treatment.

Autor: de Vries HJ; Sexually Transmitted Infection Outpatient Clinic, Health Service Amsterdam, Amsterdam, The Netherlands. h.j.devries@amc.nl, Smelov V, Middelburg JG, Pleijster J, Speksnijder AG, Morré SA
Jazyk: angličtina
Zdroj: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2009 Mar 01; Vol. 48 (5), pp. e53-6.
DOI: 10.1086/597011
Abstrakt: Microbial cure of chlamydia proctitis (lymphogranuloma venereum [LGV] and non-LGV) with doxycycline treatment was evaluated by chlamydia DNA and RNA persistence in anal swab specimens. In LGV proctitis, RNA persisted for up to 16 days. In non-LGV chlamydia proctitis, DNA was undetectable after 7 days. These findings support the Centers for Disease Control and Prevention's treatment recommendation of a 21-day doxycycline regimen for LGV proctitis and a 7-day regimen for non-LGV chlamydia proctitis. Delayed microbial cure of LGV proctitis should be considered in improved treatment regimens.
Databáze: MEDLINE