Effect of etonogestrel contraceptive implant (Implanon) on portal blood flow and liver functions.

Autor: Nasr A; Department of Obstetrics and Gynecology, Assiut University, 71516 Assiut, Egypt. a_nasr02@lycos.com, Nafeh HM
Jazyk: angličtina
Zdroj: Contraception [Contraception] 2009 Mar; Vol. 79 (3), pp. 236-9. Date of Electronic Publication: 2008 Oct 28.
DOI: 10.1016/j.contraception.2008.09.010
Abstrakt: Background: This study was conducted to evaluate changes in portal blood flow and liver functions among women using Implanon for 2 years.
Study Design: Fifty healthy Implanon users were enrolled in this longitudinal study and followed up for 24 months. Portal blood flow, assessed by color Doppler; prothrombin time and concentration; serum albumin; bilirubin; gamma-glutamyl transferase (GGT); alanine aminotransferase (ALT); and aspartate aminotransferase (AST) were measured before and 24 months after insertion.
Results: After 24 months of Implanon insertion, there were no significant changes in portal blood flow, serum albumin, prothrombin time or concentration. However, there was a significant increase in serum levels of total and unconjugated bilirubin and GGT and a significant decrease in ALT and AST levels. All levels, however, remained within the normal range of values.
Conclusions: Implanon use for 2 years does not seem to influence portal hemodynamics. Changes in serum levels of bilirubin, GGT, ALT and AST are unlikely to be of clinical significance.
Databáze: MEDLINE
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