| Autor: |
Magnanti BL; Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom., Dorak MT, Parker L, Craft AW, James PW, McNally RJ |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2009 Jun; Vol. 45 (9), pp. 1624-9. Date of Electronic Publication: 2009 Jan 27. |
| DOI: |
10.1016/j.ejca.2008.12.024 |
| Abstrakt: |
A previous study found a thyroid cancer excess in Cumbria following the Chernobyl explosion, but did not analyse sex-specific effects. This study examines sex differences in the incidence of thyroid cancer. Ninety-five primary thyroid carcinomas (69 females, 26 males) diagnosed in those aged 0-24 during 1968-2005 were identified from the Northern Region Young Persons' Malignant Disease Registry. Age-standardised incidence rates (ASRs), rate ratios (RRs) and 95% confidence intervals (CIs) were calculated. For males, the ASR was 0.6 per million person-years during the pre-Chernobyl period (1968-1986), and was 1.8 per million person-years during the post-Chernobyl period (1987-2005). For females, the ASR was 2.4 pre-Chernobyl and was 3.9 post-Chernobyl. The previously noted excess in Cumbria was entirely confined to females (Cumbrian females: RR for post-Chernobyl compared with pre-Chernobyl=10.8; 95% CI: 1.4-85.3). These findings may be consistent with sex-specific differences in susceptibility to an environmental exposure, such as fallout from the Chernobyl nuclear accident. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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Full Text from ScienceDirect