| Autor: |
Litaudon M; Institut de Chimie des Substances Naturelles, 1 Avenue de la Terrasse, UPR2301, CNRS, 91198 Gif-sur-Yvette, France. litaudon@icsn.cnrs-gif.fr, Bousserouel H, Awang K, Nosjean O, Martin MT, Dau ME, Hadi HA, Boutin JA, Sévenet T, Guéritte F |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2009 Mar 27; Vol. 72 (3), pp. 480-3. |
| DOI: |
10.1021/np8006292 |
| Abstrakt: |
In an effort to find potent inhibitors of the antiapoptotic protein Bcl-xL, a systematic in vitro evaluation was undertaken on 1470 Malaysian plant extracts. The ethyl acetate extract obtained from the bark of Meiogyne cylindrocarpa was selected for its interaction with the Bcl-xL/Bak association. Bioassay-guided purification of this species led to the isolation of two new dimeric sesquiterpenoids (1 and 2) possessing an unprecedented substituted cis-decalin carbon skeleton. Meiogynin A (1) showed the strongest activity with a K(i) of 10.8 +/- 3.1 microM. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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