| Autor: |
Gearing DP; Immunex Corporation, Seattle, WA 98101., Thut CJ, VandeBos T, Gimpel SD, Delaney PB, King J, Price V, Cosman D, Beckmann MP |
| Jazyk: |
angličtina |
| Zdroj: |
The EMBO journal [EMBO J] 1991 Oct; Vol. 10 (10), pp. 2839-48. |
| DOI: |
10.1002/j.1460-2075.1991.tb07833.x |
| Abstrakt: |
Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin-6 (IL-6) although LIF and IL-6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 'signal-transducing' component of the IL-6 receptor and to the G-CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross-hybridization and share 70% amino acid sequence identity to the human sequence. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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