| Autor: |
Martínez-Alvarez RM; Departamento de Biología, Universidad de Cádiz, Puerto Real, Spain. rosa.martinez@uca.es, Volkoff H, Muñoz-Cueto JA, Delgado MJ |
| Jazyk: |
angličtina |
| Zdroj: |
Peptides [Peptides] 2009 Apr; Vol. 30 (4), pp. 803-7. Date of Electronic Publication: 2008 Dec 27. |
| DOI: |
10.1016/j.peptides.2008.12.015 |
| Abstrakt: |
The purpose of the present study was to elucidate the possible role of calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and adrenomedullin-2/intermedin (IMD) on food intake regulation in goldfish (Carassius auratus). We examined the effects of intracerebroventricular (ICV) administration of these related hormones on food intake. Food-deprived goldfish were subjected to ICV injections of CGRP, AM and IMD and their food intake were quantified. CGRP at 10ng/g body weight (bw) significantly decreased food intake as compared to saline-treated fish. IMD at 10 and 50ng/g bw both significantly decreased food intake as compared to saline group. No significant differences were observed after AM administration. Our results suggest, for the first time in fish, a role for both CGRP and IMD in the central regulation of feeding in fish. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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Full Text from ScienceDirect