| Autor: |
Fablet M; Université Lyon 1, CNRS, UMR5558, Laboratoire de Biométrie et Biologie Evolutive, F-69622, Villeurbanne, France., Lerat E, Rebollo R, Horard B, Burlet N, Martinez S, Brasset E, Gilson E, Vaury C, Vieira C |
| Jazyk: |
angličtina |
| Zdroj: |
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2009 May; Vol. 23 (5), pp. 1482-9. Date of Electronic Publication: 2009 Jan 13. |
| DOI: |
10.1096/fj.08-123513 |
| Abstrakt: |
Combining genome sequence analysis and functional analysis, we show that some full-length copies of tirant are present in heterochromatic regions in Drosophila simulans and that when tested in vitro, these copies have a functional promoter. However, when inserted in heterochromatic regions, tirant copies are inactive in vivo, and only transcription of euchromatic copies can be detected. Thus, our data indicate that the localization of the element is a hallmark of its activity in vivo and raise the question of genomic invasions by transposable elements and the importance of their genomic integration sites. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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