| Abstrakt: |
The new family of serine/threonine protein kinases D (PKD) belongs to Ca2+/calmodulin-dependent protein kinase group. Here we review with the role of PKDs in the regulation of post-translational modification of cellular proteins. PKDs directly phosphorylate a number of cell signaling molecules, moreover PKDs indirectly regulate histone acetylation and glycosylation of proteins. The protein kinases of PKD family control physiologic cell processes, such as apoptosis, regulation of immune signaling, proliferation, adhesion and motility of cells, transmission of signals during oxidative stress. PKDs modulate signaling cascades, which are associated with ERK and JNK protein kinases, stress initiated activation of NF-kappaB. PKD dependent post-translational modifications are linked to chromatin organization, epigenetic regulation of gene expression, and also to regulation of Golgi apparatus structure and function. |
