| Autor: |
Brown AS; Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, Mailman School of Public Health, 1051 Riverside Drive, Unit 23, New York, NY 10032, USA. asb11@columbia.edu, Deicken RF, Vinogradov S, Kremen WS, Poole JH, Penner JD, Kochetkova A, Kern D, Schaefer CA |
| Jazyk: |
angličtina |
| Zdroj: |
Schizophrenia research [Schizophr Res] 2009 Mar; Vol. 108 (1-3), pp. 285-7. Date of Electronic Publication: 2009 Jan 08. |
| DOI: |
10.1016/j.schres.2008.11.018 |
| Abstrakt: |
Increased length of the cavum septum pellucidum (CSP) and in utero infection are each associated with increased risk of schizophrenia. Hence, we examined whether prenatal infections are related to CSP length in schizophrenia patients. In a well-characterized birth cohort, in utero infection was assessed using serologic biomarkers or physician diagnoses. Magnetic resonance images were acquired, and CSP length was quantified by a standard protocol. In utero infection was associated with increased CSP length in exposed schizophrenia cases compared to unexposed cases, suggesting that prenatal infection plays a role in a neurodevelopmental morphologic anomaly that has been related previously to schizophrenia. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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