Initial experience in Brazil with endoscopic submucosal dissection for early gastric cancer using insulation-tipped knife: a safety and feasibility study.

Autor: Cardoso DM; Endoscopic Unit, Department of Gastrointestinal Oncology, Araújo Jorge Cancer Hospital, Rua 239, No. 181, Setor Universitário, CEP, 74605-070 Goiânia, GO, Brazil., Campoli PM, Yokoi C, Ejima FH, Barreto PA, de Brito AM, Mota ED, de Fraga Júnior AC, da Mota OM
Jazyk: angličtina
Zdroj: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association [Gastric Cancer] 2008; Vol. 11 (4), pp. 226-32. Date of Electronic Publication: 2009 Jan 08.
DOI: 10.1007/s10120-008-0489-0
Abstrakt: Background: Endoscopic resection is an adequate treatment for subgroups of patients with early gastric cancer. Endoscopic submucosal dissection (ESD) represents a recent advance and leads to good results when adequately indicated. There is great experience with this technique in Japan and it is gaining acceptance among Western endoscopists. We present the first gastric ESD series performed in Brazil.
Methods: Patients with well-differentiated adenocarcinomas macroscopically classified as early cancer, less than 30 mm with no ulcer or scar, were included. ESD was performed with an insulated-tip knife and electrosurgical unit with endocut mode. Clinicopathological aspects and morbidity were evaluated. The study was approved by the local ethics committee and informed consent was obtained from all participant subjects.
Results: From October 2005 to July 2007, 160 patients received surgical treatment for gastric cancer; 44 patients (27.5%) had early gastric cancer. In this latter group, 15 procedures (ESD) were performed in 12 patients. The mean size of the lesions was 16.8 mm. Almost half of the lesions were located in the proximal third of the stomach and the mean elapsed time for the procedure was 140 min. In 80% of the cases resection was en bloc and 80% of the resections were considered curative. We had three perforations, which were managed clinically, and no bleeding.
Conclusion: When adequately indicated, ESD is a safe and feasible technique.
Databáze: MEDLINE
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