Optimizing safety of selective internal radiation therapy (SIRT) of hepatic tumors with 90Y resin microspheres: a systematic approach to preparation and radiometric procedures.

Autor: Schleipman AR; Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. aschleipman@partners.org, Gallagher PW, Gerbaudo VH
Jazyk: angličtina
Zdroj: Health physics [Health Phys] 2009 Feb; Vol. 96 (2 Suppl), pp. S16-21.
DOI: 10.1097/01.HP.0000333681.05581.64
Abstrakt: Arterial administration of 90Y microspheres is used for salvage therapy in patients with primary or metastasized tumors within the liver. The clinical use of high-yield beta emitters presents unique calibration, dosage measurement, and exposure monitoring tasks. This report illustrates the following issues: determination of container and volume-specific correction factors in a standard dose calibrator for various receipt and dispensing vial geometries using a U.S. National Institute of Standards and Technology-traceable 90Y standard solution; documentation of delivery and localization of the radionuclide; statistically-verified ion chamber measurements of residual (non infused) radioactivity; and measurement of occupational radiation exposures.
Databáze: MEDLINE