| Autor: |
Kalinina EV, Obraztsov VV, Shekhtman DG, Gudkova OV, Kukushkin NI, Saprin AN |
| Jazyk: |
ruština |
| Zdroj: |
Biokhimiia (Moscow, Russia) [Biokhimiia] 1991 Apr; Vol. 56 (4), pp. 714-7. |
| Abstrakt: |
Injection of perfluorodecaline to rats caused an increase of the phase II xenobiotic biotransformation enzyme activities followed by cytochrome P-450 induction. The activities of liver microsomal UDP-glucuronosyl transferase and glutathione transferase increased by 130 and 40%, respectively, against the control level. The increase of the cytosolic glutathione transferase activity was insignificant In contrast, the activity of sulfotransferase decreased about 2-fold. The role of modification of xenobiotic biotransformation enzymes in the biological effect of perfluorodecaline is discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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