Anaplasma marginale Yucatan (Mexico) Strain. Assessment of low virulence and potential use as a live vaccine.

Autor: Rodríguez Camarillo SD; Centro de Investigaciones Disciplinarias, en Parasitología Veterinaria, Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, Secretaría de Agricultura, Ganadería, Desarrollo Rural, Pesca y Alimentació, Jiutepec, Morelos, Méxcio., García Ortiz MA, Rojas Ramírez EE, Cantó Alarcón GJ, Preciado de la Torre JF, Rosario Cruz R, Ramos Aragón JA, Aboytes Torres R
Jazyk: angličtina
Zdroj: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2008 Dec; Vol. 1149, pp. 98-102.
DOI: 10.1196/annals.1428.067
Abstrakt: Anaplasma marginale Yucatan strain was found to have low virulence in cattle. We studied the virulence of this isolate by experimental inoculation of 113 susceptible cattle at increasing doses, after which only one animal required treatment for clinical disease. Subsequently, 104 cattle received a live vaccine of this strain by inoculation, which induced immunoprotection after heterologous challenged exposure with a different A. marginale isolate. In this study 14% of the immunized cattle required treatment as compared with the control nonimmunized cattle, in which 56% required treatment. The A. marginale vaccine strains used for the immunization studies had MSP1a variable regions that were different from those used for the challenge exposure.
Databáze: MEDLINE
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