| Autor: |
Schvartz YSh; Institute of Therapy, Siberian Division of Russian Academy of Medical Sciences; Institute of Biochemistry, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk., Polyakov LM, Dushkin MI, Pivovarova EN |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2008 Apr; Vol. 145 (4), pp. 430-2. |
| DOI: |
10.1007/s10517-008-0109-3 |
| Abstrakt: |
Changes in electrical charge and clearance rate of LDL after the formation of their complexes with bacterial LPS were studied in experiments on Wistar rats. It was found that binding of S. minnesota R595 LPS with (125)I-LDL sharply accelerated clearance of the greater part of LDL complexes, but on the other hand induced the appearance of an LDL-LPS subfraction with slower elimination rate compared to free LDL. Electrophoresis showed that after binding of LPS, LDL acquired a negative charge. These data suggest that the formation of LDL-LPS complexes is accompanied by modification of LDL due to which they acquire atherogenic properties. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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