| Autor: |
Schwartz YSh; Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. Russia. yshschwartz@mail.ru, Dushkin MI, Komarova NI, Vorontsova EV, Kuznetsova IS |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2008 Jun; Vol. 145 (6), pp. 692-5. |
| DOI: |
10.1007/s10517-008-0175-6 |
| Abstrakt: |
We studied the effect of high-cholesterol diet and factors inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase on the development of liver fibrosis in C57Bl/6 mice with CCl4- or zymosan-induced hepatitis. Feeding a high-cholesterol diet led to a sharp increase in collagen content in the liver tissue of animals with CCl4-induced or zymosan-induced hepatitis. Atorvastatin and calcitriol produced less pronounced fibrogenic effects. Mevalonate partially prevented the development of cholesterol-induced fibrogenesis. High-cholesterol diet led to accumulation of oxysterols, cholesterol esters, and triglycerides and increased the expression of transforming growth factor-beta1 mRNA in liver tissue. Cholesterol-induced potentiation of the fibrogenic response is probably associated with transforming growth factor-beta1 induction due to accumulation of lipids and oxysterols in the liver. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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