Expression of CD147 mediates tumor cells invasion and multidrug resistance in hepatocellular carcinoma.

Autor:	Jia L; Department of Biochemistry, Institute of Glycobiology, Dalian Medical University, Dalian, China., Xu H, Zhao Y, Jiang L, Yu J, Zhang J
Jazyk:	angličtina
Zdroj:	Cancer investigation [Cancer Invest] 2008 Dec; Vol. 26 (10), pp. 977-83.
DOI:	10.1080/07357900802072723
Abstrakt:	Multidrug resistant (MDR) tumor cells over-expressing P-glycoprotein exhibit variation in invasive behavior. To investigate the mechanisms, we analyzed the expression of CD147. The results showed that CD147 expression was increased in HepG2/Adr cells, as compared to HepG2 cells. The MDR cells produced more MMP11 and MDR1, which promoted HepG2/Adr cells invasion and increased resistance to chemotherapeutic drugs. On the other hand, CD147 silencing in HepG2/Adr cells by RNAi led to the opposite effect. Treatment of tumor cells with U-0126, an inhibitor of MAPK/Erk, also down-regulated MMP11 and MDR1 expression. Thus, CD147 may functionally mediate tumor cells invasion and MDR.
Databáze:	MEDLINE
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