| Autor: |
Polo PA; Department of Physiological Sciences, Institute of Biology, Federal Rural University of Rio de Janeiro, BR465, Km07, Seropédica, RJ 23890-000, Brazil., Mecawi AS, Lapa MA, Côrtes WS, Reis LC |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology [J Comp Physiol A Neuroethol Sens Neural Behav Physiol] 2009 Mar; Vol. 195 (3), pp. 247-52. Date of Electronic Publication: 2008 Dec 09. |
| DOI: |
10.1007/s00359-008-0402-7 |
| Abstrakt: |
The present study was carried out to investigate the influence of GABAA signaling on sleep-like behaviors through systemic administration of bicuculline and picrotoxin (GABAA antagonists) and thiopental (an allosterical modulator). A thiopental (20 mg/kg) injection increased the eye closure frequency compared to the control group. The birds quickly became sleepy with a low frequency of early behavioral stages, such as rapid oral movement (ROM), feather ruffling and blinking. A bicuculline administration (1 and 4 mg/kg) did not modify the frequency of feather ruffling, ROM, eye closure or blinking responses. A lower dose of picrotoxin (2 mg/kg) stimulated an active awakening status, while an intermediate dose (4 mg/kg) elicited a moderate awakening status, which was associated with an increase in the frequency of ROM, blinking and eye closure. At the higher dose (8 mg/kg), the birds exhibited thermoregulatory-like behaviors and convulsions immediately after the injection. Interestingly, picrotoxin (4 mg/kg) intensified the eye closures when given in combination with thiopental (20 mg/kg). Both barbiturate and picrotoxin-induced sleep-like responses have the same behavioral neuropharmacological properties, conceivably because they are correlated with action at an identical site on the GABAA receptor. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink