The physicochemical and antibacterial properties of ciprofloxacin-Mg2+ complex.
| Autor: | Adepoju-Bello AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos., Coker HA, Eboka CJ, Abioye AO, Ayoola GA |
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| Jazyk: | angličtina |
| Zdroj: | Nigerian quarterly journal of hospital medicine [Nig Q J Hosp Med] 2008 Jul-Sep; Vol. 18 (3), pp. 133-6. |
| Abstrakt: | Purpose: Co-administration of quinolone antibiotics with cation-containing medicaments such as, antacids has been reported to influence the overall bioavailability leading to subtherapeutic plasma concentrations of these antibiotics in humans. Objectives of the Study: The present work was designed to evaluate the binding constant, binding molar ratio, influence of temperature on the binding constant of ciprofloxacin-Mg2+ and to determine the antimicrobial activity of ciprofloxacin and ciprofloxacin-Mg2+. Methods: Job's method of continuous variation and Bonesi-Hildebrand equation were adopted to determine the molar ratio and stability constant respectively. The antibacterial activity was determined by the Agar diffusion method. Results: A complexation molar ratio of 1:1 was obtained for ciprofloxacin-Mg2+ complex. The stability constants were 3.59 and 3.50 at 25 degrees C and 60 degrees C respectively. There was a significant difference between the zones of inhibition of ciprofloxacin-Mg2+ complex and that of ciprofloxacin alone against E. coli, P. aeruginosa, and S. aureus (p < 0.05). This difference showed that the complex formed was not as active as ciprofloxacin. Conclusion: The present studies have shown that ciprofloxacin readily complex with Mg2+ and that the stability constant was temperature dependent. The antibacterial activity of ciprofloxacin was markedly reduced in the presence of Mg2+. Concomitant administration of ciprofloxacin with Mg2. containing medicaments should be avoided to prevent resistance. |
| Databáze: | MEDLINE |
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