Enumeration of blood dendritic cells in patients with multiple myeloma at presentation and through therapy.

Autor:	Harrison SJ; Haematology Service, Peter MacCallum Cancer Centre, Melbourne, Australia. simon.harrison@petermac.org, Franklin IM, Campbell JD
Jazyk:	angličtina
Zdroj:	Leukemia & lymphoma [Leuk Lymphoma] 2008 Dec; Vol. 49 (12), pp. 2272-83.
DOI:	10.1080/10428190802464729
Abstrakt:	Multiple myeloma (MM) is a clonal B-cell malignancy characterised by excess bone marrow plasma cells, serum and/or urine paraprotein, immune paraesis, renal failure and lytic bone lesions. Dendritic cells (DC) are key players in the adaptive and innate immune responses, but reside in tissues, so are difficult to quantify in vivo. By enumerating the blood DC pool, we aim to examine the influence of MM disease and accompanying therapy on the DC system. We have shown, using the BDCA DC detection kit, that blood pDC and mDC numbers are suppressed at diagnosis in MM, and uniquely, monoclonal gammopathy of uncertain significance (MGUS) and patients with plasmacytoma. B-cell numbers were also significantly reduced in MM, MGUS and patients with plasmacytoma (p
Databáze:	MEDLINE
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