Short course of radiation therapy in elderly patients with glioblastoma multiforme.

Autor: Idbaih A; Service de radiothérapie oncologique, pavillon Antonin-Gosset, groupe hospitalier Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France., Taillibert S, Simon JM, Psimaras D, Schneble HM, Lopez S, Lang P, Toubiana T, Feuvret L, Delattre JY, Mazeron JJ
Jazyk: angličtina
Zdroj: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique [Cancer Radiother] 2008 Dec; Vol. 12 (8), pp. 788-92. Date of Electronic Publication: 2008 Nov 28.
DOI: 10.1016/j.canrad.2008.05.007
Abstrakt: Purpose: The optimal schedule of irradiation in elderly patients suffering from glioblastoma multiforme (GBM) is unsettled.
Materials and Methods: This study reviewed the charts of 28 consecutive GBM patients aged 70 years or more with a Karnofsky Performance Status (KPS) greater than or equal to 70 who received a short course of radiotherapy (40 grays in 15 fractions over three weeks).
Results: The median age at surgery was 74.6 years (range, 70.1-85.7). No patient received prior or concomitant chemotherapy. The median progression-free survival and overall survival were 21.6 weeks (95% CI, 17.0-39.9) and 50.6 weeks (95% CI, 26.3-62.0), respectively. Even within a narrow range (<90 or >or=90), KPS remained a prognostic factor (p=0.03). Tolerance appeared acceptable in terms of KPS changes and corticosteroid use during radiation therapy.
Conclusion: These results support the efficacy of short schedule radiotherapy for GBM in elderly patients with a good KPS.
Databáze: MEDLINE
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